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KMID : 0363020050350020401
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Journal of Korean Academy of Periodontology
2005 Volume.35 No. 2 p.401 ~ p.411
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Antimicrobial effect of cefixime on 6 species of periodotopathogens
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장현선
박문규/국중기/김화숙/김병옥
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Abstract
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The aim of this study was to determine the minimal inhibitory concentration(MIC) of cefixime, which is a 3rd generation of cefalosporin, against 6 species of putative periodontopathogens; Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Prevotella nigrescens, Tannerella forsythia and Porphyromonas gingivalis. The efficacy
of cefixime was examined by comparing it with that of several antibiotics(amoxicillin, Augmentinⓡ ciprofloxacin, metronidazole, and tetracycline), which were used as the control. The
MIC was measured using a microdilution method. The MIC of cefixime against the putative
periodotopathogens, as a single use regimen, was relatively lower than that of the other
antibiotics. The MIC of cefixime/metronidazole against P. intermedia ChDC KB14, P. nigrescens ChDC KB50, F. nucleatum ChDC PV-F37, F. nucleatum ChDC F130, and F. nucleatum
ChDC F175, as a simultaneous regimen, was lower than that of the other antibiotics. The
concentration of cefixime in the crevicular fluid of volunteers who received 250mg every 12
hours for 3 days was 9㎍/ml after 9 hours. In conclusion, cefixime showed good antimicrobial activity in a single treatment or as a combined therapy with amoxicillin, Augmentinⓡ or metronidazole against 6 periodontopathogens.
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KEYWORD
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Minimal inhibitory concentraion, MIC, cefixime
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